Blood Donation Safety Procedures: An Overview

Blood Donation Safety Procedures: An Overview Qualification of blood donors has become a lengthy and detailed process, a donor inquisition some would say. Yet blood collection depends on this system of safeguards to protect the donor from injury and the recipient from the risks of allogeneic blood. Sensitive screening tests have been considered the cornerstone of blood safety for more than three decades. However, testing represents only one component of this system. Additional layers of safety include following measures:- Detailed donor education programmes prior to recruitment, Pre-donation informational literature, Stringent donor screening selection and deferral procedures, Post-donation product quarantine Donor tracing and notification when instances of disease transmission are detected. Each element plays a role in preventing tainted units from entering the blood inventory. Most transfusion services have developed evidence-based standards and regulations for the selection of donors and quality systems to assure excellence in all phases of their application. Other standards derive from expert opinion and common sense, and these policies need to be revisited as scientific information becomes available. Blood donors should have the following general qualifications:- They should have reached the age of consent, most often 18 years, but 17 in some countries such as the USA and the UK; They should be in good health, They should have no history of serious illness, Must weigh enough to allow safe donation of a unit and not recognize themselves as being at risk of transmitting infection. Ideally, donation should be strictly voluntary and without financial incentive. Some blood services impose an arbitrary upper limit on age, commonly 65 years, or up to age 70 in Denmark and the UK; however, it seems curiously subjective to exclude donors on the basis of age alone if they are otherwise in good health. The Blood Collection Service should provide informational literature for prospective blood donors. After information and counselling about criteria for donor selection, donors should consent in writing to the terms of donation, including the use of the donated  blood, the extent of testing, the use of testing results (including donor notification of positive results) and the future use of any stored specimens. Donors should be told about the possibility of delayed fainting and about other significant risks of the donation procedure. Blood donation has potential medicolegal consequences. If a donor becomes ill shortly after giving blood, the illness may be attributed to blood donation For this reason, among others, it is important to ensure that donors have no history of medical conditions such as brittle diabetes, hypertension, poorly controlled epilepsy and unstable cardiopulmonary disease that might be associated with an adverse event following phlebotomy. Pregnancy might be adversely affected by the donation process and ordinarily excludes a donor. Donors who become ill within 2 weeks of donation should be encouraged to inform the transfusion service, which may wish to discard the donated blood, recall any plasma sent for fractionation or follow up recipients of the blood components as appropriate. Donors who develop hepatitis or HIV infection within 3-6 months of donation should also i nform the Blood Collection Service. Donor interview The donor interview should be conducted by staff trained and qualified to administer questions and evaluate responses. The donor interview should be conducted in a setting sufficiently unhurried and private as to permit discussion of confidential information. With current practices in the USA, approximately 2% of volunteer donors still disclose risks that would have led to deferral at the time of donation. Introduction of standardized and validated questionnaires and the application of interactive computer-assisted audiovisual health history may reduce errors and misinterpretations during conduct of the donor interview. Physical examination Blood collectors perform a limited physical examination designed to protect donor and recipient. Screeners routinely assess the donors general appearance and defer those who do not appear well or are under the influence of alcohol. A normal range of pulse and blood pressure is defined, although variances may be granted for healthy athletes. Body weight and temperature are measured by some collection services. Both arms are examined for evidence of illicit drug use and for lesions at the venepuncture site. Volume of donation The volume of anticoagulant solutions in collection bags is calculated to allow for collection of a particular volume of blood, which, in the UK, is 450  ± 45 ml. In the USA often 500 ml, but in no case more than 10.5 ml/kg including the additional volume of 20-30 ml of blood collected into pilot tubes. From donors weighing 41-50 kg, only 250 ml of blood is collected into bags in which the volume of anticoagulant solution has been appropriately reduced. In some countries, the volume collected routinely is less than 450 ml, for example 350-400 ml in Turkey, Greece and Italy, and 250 ml in some Asian countries such as Japan, where donors tend to be smaller. Record-keeping It should be possible to trace the origin of every blood donation and records should be kept for several years, depending on the guidelines for each country. In many countries, a system employing unique bar-coded eyereadable donation numbers is now in use. This system makes it possible to link each donation to its integral containers and sample tubes and to the particular donor session record. Information concerning previous donations, such as records of blood groups and microbiology screening tests, antibodies detected, donor deferrals and adverse reactions are important for subsequent attendances. Electronic storage of donor information greatly facilitates accurate identification, release, distribution and traceability of units of blood and blood products. An international code, ISBT 128, is intended to be used by all countries for the accurate identification of donors and donations. These records must be protected from accidental destruction, modification or unauthorized access. Frequency of donors in the population Although in many Western countries, some 60% of the population are healthy adults aged 18-65 years and thus qualified to be blood donors, the highest annual frequency of donation in the world corresponds to about 10% of the population eligible to give blood donating once per year, as in Switzerland. The frequency in most developing countries is less than 1% . The number of units collected per 1000 US inhabitants of usual donor age (18-65) was 88.0 in 2001, up from 80.8 in 1999. Although this number compares favourably with the rate of 72.2 per 1000 in 1997, it pales in comparison with the 100 units per 1000 population collected in Switzerland. As treacherous as it may be to interpret these figures, the numbers suggest that US collecting facilities are progressively improving efficiency. Data from the American National Red Cross indicate that the average volunteer donates about 1.7 times a year. Losses from outdated red cells accounted for 5.3% of the supply but, given the fact that r ed cells can be transfused only to compatible recipients, the number of usable units outdated appears to be extremely small. More than 99% of group O units and 97% of group A units were transfused. The shrinking donor pool: the safety vs. availability conundrum Donor deferrals and miscollected units have an increasing role in blood shortages. In a 1-year study at a regional blood centre, nearly 14% of prospective donors were ineligible on the day of presentation and more than 3.8% of donations did not result in the collection of an acceptable quantity of blood. Short-term deferral for low haemoglobin (Hb) was the overwhelming reason for the deferral of female donors in all age groups, representing more than 50% of all short-term deferrals. In first-time female donors, low Hb accounted for 53-67% of deferrals within different age groups, and for repeat female donors 75-80% of deferrals. In both firsttime and repeat male donors aged 40 years and older, the most common reason for short-term deferral was blood pressure or pulse outside allowed limits. For persons aged 16-24 years, regardless of sex and donation  status, the most common reason for lengthy deferral was tattoo, piercing or other non-intravenous drug use needle exposure. For 25- to 39-year-old female donors, needle exposure was also the most common reason, whereas for male donors, travel to a malarial  area was more common. For all ages over 40, the most common reason for long-term deferral was travel to a malarial area. Measures introduced to increase blood safety may  have the unintended consequence of decreasing blood availability. Results from demographic studies indicate that certain donor groups or donor sites present an unacceptable risk of disease transmission. For example, blood collectors no longer schedule mobile drives at prisons or institutions for the disabled because of the recognized high prevalence of transfusion-transmissible viruses. Few would argue the risk-benefit analysis of these exclusions. More questionable were the temporary exclusions of US soldiers exposed to multiple tick bites at Fort Chaffee, Arkansas, and the lengthy deferrals of veterans who served in Iraq and Kuwait because of the fear that they might harbour Leishmania donovani, an agent infrequently associated with transfusion risk. Donors who have received human growth hormone injections have been indefinitely deferred because of the possible risk of transmitting Creutzfeldt- Jakob disease (CJD); however, relatives of patients with sporadic CJD are still deferred in the US (except for preparation of plasma fractions) despite evidence of their safety. There have now been five case-control studies of more than 600 CJD cases, two look-back studies of recipients of CJD products, two autopsy studies of patients with haemophilia and mortality surveillance of 4468 CJD deaths over 16 years without any link to transmission by transfusion (Centers for Bio logic Evaluation and Research, US Food and Drug Administration 2002). Although the impact of this deferral on the US blood supply has been negligible, the recent indefinite deferral of donors who resided in the UK for a total of 3 months or longer between 1980 and 1996, and the complicated deferral policy for residents and visitors to the European continent, designed to reduce a calculated risk of transmission of the human variant of mad cow disease (variant Creutzfeldt-Jakob disease, vCJD), has had a substantial impact, a loss of as much as 10% by some estimates, particularly on apheresis donors (Custer et al. 2004). Additional donor exclusions appear to be on the horizon. Donor medications constitute another significant area of deferral losses. Certain medications, for example etretinate (Tegison), isotretinoin (Accutane), acitretin (Soriatane), dutasteride (Avodart) and finasteride (Proscar), have been identified as posing potential risk to transfusion recipients because of their teratogenic potential at low plasma concentrations. Such exclusions have little impact on blood safety but each shrinks the potentially eligible volunteer donor pool. More troublesome, although not as numerous, are donor deferrals resulting from false-positive infectious disease screening tests. This problem has been recognized since the introduction of serological tests for syphilis. However, during the past 15 years, the introduction of new screening tests and testing technologies has resulted in numerous deferrals for questionable test results and either complex re-entry algorithms or no approved method to requalify such donors. Surrogate tests used for screening have pro ved particularly troublesome. However, even specific tests result in inappropriate deferrals. Of initial disease marker-reactive donations, 44% proved to be indeterminate or false positive. Each year an estimated 14000 donors are deferred from donating blood for an indefinite period because of repeatedly reactive enzyme immunoassay (EIA) screening tests for human immunodeficiency virus (HIV) and hepatitis C virus (HCV), and several hundred donors are deferred for apparently false-positive nucleic acid testing (NAT) results. Registry of bone marrow donors Voluntary blood donors are highly suitable to become bone marrow or peripheral blood stem cell donors for unrelated recipients, and many transfusion services now recruit them for this purpose. From its founding in 1986 until August 2003, the National Marrow Donor Program in the USA had registered more than 5 million bone marrow and blood stem cell donors, and Bone Marrow Donors Worldwide in the Netherlands records more than 8 million donors from 51 registries in 38 countries. Standards for acceptance of stem cell donors are based on blood donor eligibility. A uniform donor history is being developed. Conditions that may disqualify a donor Carriage of transmissible diseases The most important infectious agents transmissible by transfusion are the hepatitis viruses B and C, HIV, human T-lymphotropic viruses (HTLVs), bacteria and the agents causing malaria and Chagas disease. Increasing attention is being paid to the risks of emerging agents and newly recognized infectious risks of transfusion such as West Nile virus, babesiosis and vCJD. Steps that should be taken to minimize the risk of infecting recipients with the agents of these and other diseases involve exclusion based on geographical residence, signs and symptoms of disease, high-risk activity and demographics associated with risk transmission. Donors who have been exposed to an infectious disease and are at risk of developing it should be deferred for at least the length of the incubation period. Recent inoculations, vaccinations, etc. To avoid the possibility of transmitting live viruses (e.g. those of measles, mumps, rubella, Sabin oral polio vaccine, yellow fever, smallpox), donors should not give blood during the 3 weeks following vaccination. In subjects immunized with killed microbes or with antigens (cholera, influenza, typhoid, hepatitis A and B, Salk polio, rabies, anthrax, tick-borne and Japanese encephalitis) or toxoids (tetanus, diphtheria, pertussis), the interval is normally only 48 h. These recommendations apply if the donor is well following vaccination. Plasma from recently immunized donors may be useful for the manufacture of specific immunoglobulin preparations. Donors who have received immunoglobulins after exposure to infectious agents should not give blood for a period slightly longer than the incubation period of the disease in question. If hepatitis B immunoglobulin has been given after exposure to the virus, donation should be deferred for 9 months to 1 year; similarly, if tetanus immunoglo bulin has been given, donation  should be deferred for 4 weeks. When rabies vaccination follows a bite by a rabid animal, blood donations should be suspended for 1 year. In developed countries, tetanus and diphtheria immunoglobulin is derived from human sources. However, horse serum is still  used in some parts of the world. Donors who have received an injection of horse serum within the previous 3 weeks should not donate blood because traces of horse serum in their blood might harm an allergic recipient. The administration of normal human immunoglobulin before travelling to countries where hepatitis A is endemic is not a cause for deferral. Group O subjects may develop very potent haemolytic anti-A following an injection of tetanus toxoid, typhoid-paratyphoid (TAB), vaccine or pepsindigested horse serum, which may contain traces of hog pepsin. In the past, the use of such subjects as universal donors sometimes led to severe haemolytic transfusion reactions in group A subjects. Platelet concentrates collected by apheresis from subjects with hyperimmune anti-A should not be used for transfusion to group A or AB patients in view of the large volume of plasma needed to suspend the platelet concentrate. Ear-piercing, electrolysis, tattooing, acupuncture   All of these procedures carry a risk of transmission of hepatitis or HIV infection when the equipment used is not disposable or sterilized, and blood donation should then be deferred for 12 months. In the UK, donors are accepted if the acupuncture is performed by a registered medical practitioner or in a hospital. Although  the association between tattooing and exposure to hepatitis C is generally acknowledged, less clear is whether a tattoo performed by licensed and inspected facilities carries more risk than a trip to the dentists surgery. Allergic subjects Subjects who suffer from very severe allergy are unacceptable as donors because their hypersensitivity may be passively transferred to the recipient for a short period. Subjects with seasonal allergy (e.g. hay fever) may donate when not in an active  phase of their hypersensitivity. A screening test for immunoglobulin E (IgE) antibodies would not help to identify those allergic individuals with an increased chance of passively transferring their hypersensitivity. Blood transfusions and tissue grafts Donations should not be accepted for at least 12 months after the subject has received blood, blood components or grafts. Increasingly, donors who have received transfusion in the UK are being deferred indefinitely as a precaution against transmission of vCJD. Surgery and dental treatment When surgery has been carried out without blood transfusion, donation may be considered when the subject has fully recovered. Uncomplicated dental treatments and extractions should not be a cause for prolonged deferral, as utensils are sterilized and the  risk of bacteraemia persisting for more than 1 h is negligible. Medication Many subjects taking medication are not suitable as donors because of their underlying medical condition. Others are unsuitable as donors because the drugs they are taking, for example anticoagulants or cytotoxic agents, may harm the recipients. Subjects who have taken aspirin within the previous week are unsuitable when theirs are the only platelets to be given to a particular recipient. Ingestion of oral contraceptives or replacement hormones such as thyroxine is not a disqualification for blood donation. On the other hand, recipients of human growth hormone (non-recombinant) should be permanently deferred from blood donation as should subjects who have used illicit injected drugs. Deferral for specific medication use is usually an issue of medical discretion. Donors with relatively minor red cell abnormalities In some populations, a considerable number of donors have an inherited red cell abnormality. The three conditions most likely to be encountered are: glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, sickle trait (HbAS) and thalassaemia trait. G-6-PD deficiency. This is the most common red cell enzyme defect; hundreds of molecular variants have been catalogued. Although most G-6-PD-deficient red cells have only slightly subnormal survival and lose viability on storage with adenine at only a slightly increased rate (Orlina et al. 1970), some enzyme variants render the cells unsuitable for transfusion. With the African variant GdA- present in 10% of African  Americans, a relatively small number of red cells are severely affected. However, the Mediterranean variant GdMediterranean and others render the red cell particularly  sensitive to oxidative stress. If the recipient of one of these units develops an infectious illness or ingests fava beans or one of any number of drugs (ph enacetin, sulfonamides, vitamin K, primaquine, etc.), rapid destruction of the donors G-6-PD-deficient cells may  result. Neonatologists avoid using G-6-PD-deficient blood for exchange transfusion, and subjects who have evidenced G-6-PD-related haemolysis should be permanently deferred from donation (Beutler 1994). Sickle trait (HbAS). Sickle trait red cells survive normally in healthy subjects, even after storage. However,  in patients subject to various types of hypoxic stress, these cells survive poorly. HbS polymerizes at low oxygen tension and the cells are trapped in the spleen. Blood from donors with sickle cell trait should not be used for infants or for patients with  sickle cell disease who undergo exchange transfusion. Patients, other than those with sickle Hb, who require general anaesthesia should have no problems if transfused  with HbAS red cells provided that adequate oxygenation is maintained. Red cells from subjects with HbAS are usually unaffected by collection via apheresis,  but those with sickling haemoglobinopathies should not donate by apheresis and are not suitable for intraoperative salvage. If blood from donors with sickle cell trait is  glycerolized for storage in the frozen state, extra wash solution must be used during the deglycerolization procedure. Sickle trait prevents ef fectiveWBC reduction by filtration. Thalassaemia trait This is associated with little or no reduction in red cell lifespan in most subjects with a normal Hb concentration and these subjects may be accepted as donors. Special conditions in which normally disqualified donors may donate In some circumstances, a donor may give blood or components to be used for a special purpose, even although the requirements for normal donation are not met. For example, a donor who is mildly anaemic or who has recently given birth may give plasma or  platelets by apheresis; the plasma may be needed for reagent preparation, for example HLA antibodies, or the platelets may be needed for transfusion to the newborn infant. Donors at risk for carrying malaria may give plasma for fractionation. The usual interval  between donations may be waived for important medical indications. The donor age limitation and a number of other screening criteria may be modified for components directed to the recipient of the donors bone marrow. In every case, medical evaluation should ensure that there is no increased risk to the donors health and that the value of the component outweighs any perceived increase in risk. Under these circumstances, informed consent regarding the variance and documentati on of the circumstances is mandatory. Donation of whole blood Frequency of donation The volume lost from a single unit donation is replaced within 48-72 h. Red cell mass recovers more slowly, requiring 3-6 weeks. Some collection services bleed donors no more than two or three times a year; most do not bleed women who are pregnant or those who have been pregnant within the previous 6 weeks. The primary objective of this policy is to protect the donor from iron deficiency. There is a wide variation in the recommended minimum interval between donations. For example in the US, in line with World Health Organization (WHO) recommendations, the interval can be as short as 8 weeks and a maximum of 3 l of blood per year may be collected. Premenopausal women should not donate as frequently as men. In the Netherlands, men are bled every 3 months and women every 6 months. Because few red cells are lost during platelet and plasmapheresis, these procedures may be performed more often and at shorter intervals. Standards vary by country; in the USA plateletpheresis donors may be dr awn every 48 h up to twice per week and 24 times per year. Commercial plasmapheresis donors are bled even more frequently; however, physical examination is more rigorous and laboratory testing more extensive for these donors. As combinations of components, such as two-unit red cells, are drawn by apheresis, volumes and intervals become individualized, but generally limited by the loss of red cells. Hb regeneration after normal blood donation In 14 normal healthy subjects bled of about 400 ml of blood (8% of their blood volume), circulating reticulocytes increased minimally but significantly and peaked on the ninth day after bleeding. The Hb level was lowest 1 or 2 weeks after bleeding, and increased rapidly thereafter, reaching predonation levels at 3-4 weeks (Fig. 1.1). In a study in which total red cell volumes were measured in subjects who had donated about 190 ml of red cells, about 50 ml of red cells were restored after 1 week and restoration was  almost complete at 6 weeks. Potential health benefits of blood donation For the volunteer donor, the chief benefit lies in the satisfaction of selfless concern for the welfare of others. However, two studies suggest that there may be more tangible health benefits, particularly for middle-aged men, such as lowering the risk of cardiovascular disease. The proffered explanation derives from the so-called iron hypothesis: menstrual iron loss protects women against cardiovascular disease; iron stores correlate with cardiovascular disease across European populations and heart failure is a hallmark of disorders of iron surplus (Sullivan 1981). One proposed mechanism for this association is generation of oxygen free radicals that induce oxidation of lipids. However  the Johns Hopkins Hospital autopsy registry found less coronary artery disease in hearts from patients with haemochromatosis and haemosiderosis than in hearts of age- and sex-matched controls. Salonen and co-workers (1998) conducted a prospective 9-year follow-up study of 2862 men aged 42-60 from eastern Finland, who had participated in the Kuopio Ischemic Heart Disease Risk Factor Study. Only one man out of 153 who had donated blood in the 24 months prior to baseline examination suffered a myocardial infarction, compared  with 316 (12.5%) of the 2529 non-donors. Meyers and co-workers (1997) compared the rate of cardiovascular events of 665 blood donors with that of  3200 non-donors in a telephone survey of a cohort selected from the Nebraska Diet Heart Survey. By multivariate analysis, non-smoking men who had donated at least once in the previous 3 years had a significantly lowered risk of cardiovascular events; no additional benefit was derived from longer or more frequent donation. Directed donations are those given exclusively for named patients, usually by relatives or friends. The use of directed donations contravenes the normal principles of voluntary blood donation, fails to increase  safety and finds medical justification in vanishingly few circumstances: in patients with rare blood groups when the only available compatible donors may be close relatives; in occasional patients awaiting renal transplants, for whom donor-specific transfusions may still play a role; in infants with neonatal alloimmune  thrombocytopenia or haemolytic disease of the newborn, for whom maternal platelets or red cells are occasionally invaluable; (4) in children requiring open-heart or extensive orthopaedic surgery, for whom the total requirements for blood and components can be collected preoperatively, as for autologous transfusion but from designated relatives or parents, thus minimizing the number of donor units to which the children are exposed in  patients with leukaemia in relapse after bone marrow transplantation, for whom donor leucocytes are used as adoptive immunotherapy to induce graft-versusleukaemia  (GvL) effect. The practice of transfusing parental blood to premature newborn infants is not without risks. Mothers may have antibodies against antigens (inherited from the father) on the infants red cells, platelets or white cells and maternal plasma should not be used. Fathers should not serve as cell donors because they may have antigens present on their red cells, which are incompatible with maternally derived antibodies present in  the fetus. Moreover, in view of partial histocompatibility, transfusion of cells from parents and close relatives may result in graft-versus-host disease (GvHD) in  the infants, or older children, especially if the infants are immunodeficient. Circumstances such as these, in which blood or platelet suspensions should be irradiated, are described in. The practice of transfusing parents with blood from their offspring can also be dangerous. Fatal GvHD occurred in two immunocompetent adult patients who  were transfused with fresh whole non-irradiated blood from their children during cardiac surgery. In both cases, one of the donors was homozygous for one of the recipients HLA haplotypes. When such transfusions are indicated, and except for instances in which adoptive immunotherapy is intended, the components should be treated with 25 Gy gamma irradiation. People who donate for friends and family lose their  anonymity and may be subject to influences not placed upon community donors. Such donors may provide less than candid answers to sensitive donor questions, either because they believe that unsafe blood will inevitably be detected by testing procedures or because they wish to conceal information from the recipient or the blood collector.

Interpretation Project

So you also must be ready, because the Son of Man will come at an hour when you do not expect him† (Lucas, New Kings James Version). Jesus shares Insight for humanity prior to HIS return, In efforts that mankind may be prepared to receive the Lord and not be deceived. If people use consideration when interpreting God's meaning and not personal interpretations, the true message can be revealed. According to Journey into God's Word, â€Å"We believe that the way to approach the Bible (I. E. , the way we listen to God) should match how God gives us the Bible (I. E. , chose to speaks' (Devalue & Hayes, 2008, p. 0). This short story ay be viewed as Jesus being Like a thief and coming at an unexpected time; discovered. Jesus provides all humanity with the necessary preparations for the end times. Jesus reveals His love and concern for humanity by revealing signs of the tribulation. â€Å"Nation will rise against nation†¦ There will be famines and earthquakes†¦ † (Ma tt. 24:7). These are given in efforts to bring awareness that until these pass, the end is not here. Jesus will be returning at an unknown day, hour, and season. His return is not even known to â€Å"†¦ Angels, nor the Son, only the Father† (Matt. 4:36). He includes warnings and precautions. Jesus warns against false teachings, and prophets that will arise and claim to be the messiah. Man is to be cautious that he is not lead astray by the â€Å"thief† that will come to deceive. Jesus uses the parable of the thief and the master of the house. If mankind knows when His return will be, man would most likely live in darkness until the time approached. Then deception would be avoided by waiting for the very day and hour of His return and many may not accept Him until the last minute and not spread the Gospel until the end times.As stories are mentioned, people read the parable regarding the fig tree and fleet on the prophecy spoken in Daniel; these are pieces of the a rmor of God to keep the â€Å"elect† from being deceived by the true deceiver. â€Å"So when you see standing in the holy place the abomination that causes desolation'†¦ † (Matt. 24:15,). People who know God will know this is the â€Å"thief† that has come to steal salvation. As many become like the parable of the fig tree, they become fruitless and the Word of God will have been spoken and not heard. This is when the time to watch that The Lord will be arriving soon after these things has been fulfilled.He then shares with us the story of Noah. This story is included to reveal the swiftness of His return. Any who have lived an ungodly life â€Å"as determined by the Son of Man† will be cast among the hypocrites (Matt. 24:51). Jesus desires humanity to accept the gift of salvation and live unto Him; only by adhering to these warnings can mankind be prepared for the Lord's return.

Ophelia Parker’s Moment with Chanel

They wore soft fur coats; shiny, ivory colored pearls upon their necks; slinky satin dresses; and carefully crafted leather high heeled shoes. These ere the rich and famous women of the Big Apple, the Broadway actresses, the wives of millionaires, or as I called them, the â€Å"Fur Coat Ladies. † They all exuded glamour, which l, Aphelia Parker, wanted more than anything. But instead of that, I got living in a middle class environment and going to a regular high school.But I was lucky enough to marry my high school sweetheart, James Richard Parker. We were madly in love, so it was pretty easy to convince him to save up enough money for a honeymoon in Paris, France. Honeymooning in Paris is exciting by itself, but I had no idea what amazing opportunity it had in store for me. On February 5, 1954, at around nine in the morning, I went on a walk by myself through town. Except this was not the town I usually walked through, for it was Paris, France.I was aware of the fact that Coc o Channel, also known as my role model, was holding her well anticipated comeback show in Paris that day. I wanted to get a ticket, but they were sold out. As I walked past the venue of the show, there were already many well-dressed people, most of them with cameras and notepads, hoping to sneak a peek at the new collection. And that was when I Molly FOX @02927528 saw her: the most glamorous woman in the world, the woman to whom I looked up the most, Coco Channel, was within walking distance of me.I was staring intensely at her impeccable outfit: a small, black wool hat, a glossy pair of pearl drop earrings that were matched up with an even glossier pearl necklace, a black and white tweed skirt suit, a silky black shirt, sheer black stockings, and carefully crafted leather high heeled shoes. I then saw her pointing at me and a feeling of fear quickly came over me. Immediately after that, Coco and a young man in a well-tailored suit walked over to me. The man asked me, in French, if I could model, and being fluent in French, I answered that I could.Coco and the man told me to come with them, and before I knew it, I was whisked into the magical world of fashion. The scenario that was occurring at Coco's show was that one of her models had abruptly fallen ill, and I was literally pulled from the streets to take her place. While standing nervously backstage, I was handed one of the most flawless outfits I had ever seen: a perfectly stitched Ana suit. It contained a box Jacket and pants; a matching Ana bootee made of cotton; a crisp, white button down shirt; and carefully crafted leather high heeled shoes.I was told not only that this is the outfit that I would be wearing onstage but that I would be the first model to walk across the runway! All I had to do was simply walk to the end of the runway, turn around, and walk backstage. That is exactly what I did when it was time to do so. I can still vividly remember the hot, bright stage light shining down on me as if it was the Sun, the licked-clack of the high heeled shoes on the smooth runway, and the feeling of hundreds of pairs of eyes fixated on me, a regular girl from the United States of America, modeling in Coco Channel's comeback show in Paris.After Coco gave me 400 Euros for filling in for the sick model, I resumed my honeymoon with James. When we got back to New York City, I went back to witnessing at an Italian restaurant, and he went back to work in construction. We eventually got teaching Jobs at our old high school, with James teaching mathematics and me teaching French. I was also the proud owner of a youth theater until I sold it in 1992, which was also the year I retired from teaching.Two of its biggest stars were my daughters, Betty and Sally, who both went on to be actresses on Broadway. James passed away yesterday morning in his sleep, and while going through his belongings, I discovered the pictures of our honeymoon, bringing me back to this experience. It made me realize t hat even though I never became a â€Å"Fur Coat Lady,† being the first model in Coco Channel's comeback show was Just as great in my opinion. Ophelia Parker’s Moment with Chanel These were the rich and famous women of the Big Apple, the Broadway actresses, the wives of millionaires, or as I called them, the â€Å"Fur Coat Ladies. † They all exuded glamour, which I, Aphelia Parker, wanted more than anything. But Instead of that, I got living In a middle class environment and going to a regular high school. But I was lucky enough to marry my high school sweetheart, James Richard Parker. We were madly In love, so It was pretty easy to convince him to save up enough money for a honeymoon in Paris, France. Honeymooning in Paris Is excellent by Itself, but I had no Idea what amazing opportunity it had in store for me.On February 5, 1954, at around nine in the morning, I went on a walk by myself through town. Except this was not the town I usually walked through, for it was Paris, France. I was aware of the fact that Coco Channel, also known as my role model, was holding her well anticipated comeback show in Paris that day. I wanted to get a ticket, but they were sold out. As I walked past the venue of the show, there were already any well-dressed people, most of them with cameras and notepads, hoping to sneak a peek at the new collection.And that was when I Molly saw her: the most glamorous woman In the world, the woman to whom I looked up the most, Coco Channel, was within walking distance of me. I was staring intensely at her impeccable outfit: a small, black wool hat, a glossy pair of pearl drop earrings that were matched up with an even glossier pearl necklace, a black and white tweed skirt suit, a silky black shirt, sheer black stockings, and carefully crafted leather high led shoes. I then saw her pointing at me and a feeling of fear quickly came over me. Immediately after that, Coco and a young man in a well-tailored suit walked over to me.The man asked me, in French, if I could model, and being fluent in French, I answered that I could. Coco and the man told me to come with them, and before I knew It, I was whisked Into the ma gical world of fashion. The scenario that was occurring at Cocas show was that one of her models had abruptly fallen Ill, and I was literally pulled from the streets to take her place. While tanning nervously backstage, I was handed one of the most flawless outfits I had ever seen: a perfectly stitched Ana suit. It contained a box jacket and pants; a crafted leather high heeled shoes.I was told not only that this is the outfit that I would be wearing onstage but that I would be the first model to walk across the runway! All I had to do was simply walk to the end of the runway, turn around, and walk backstage. That is exactly what I did when it was time to do so. I can still vividly remember the hot, bright stage light shining down on me as if it was the Sun, the illicit-clack of the high heeled shoes on the smooth runway, and the feeling of hundreds of pairs of eyes fixated on me, a regular girl from the United States of America, modeling in Coco Channel's comeback show in Paris. Af ter Coco gave me 400 Euros for filling in for the sick model, I resumed my honeymoon with James. When we got back to New York City, I went back to witnessing at an Italian restaurant, and he went back to work in construction. We eventually got teaching Jobs at our old high school, with James teaching mathematics ND me teaching French. I was also the proud owner of a youth theater until I sold it in 1992, which was also the year I retired from teaching.Two of its biggest stars were my daughters, Betty and Sally, who both went on to be actresses on Broadway. James passed away yesterday morning in his sleep, and while going through his belongings, I discovered the pictures of our honeymoon, bringing me back to this experience. It made me realize that even though I never became a â€Å"Fur Coat Lady,† being the first model in Coco Channel's comeback show was Just as great in my opinion.

U.s. Immigration Policy Over Time - 1611 Words

Essay Two (US Immigration Policy Over Time) 1. Essentially, the United States was built by immigrants, who sought to make a new life in a new land. In this case therefore, before the 1880s, almost anyone could move in to the United States. Immigration would only start to be controlled once the population began to grow. While the first Europeans from Britain arrived in America to avoid persecution, own lands, and work on agriculture etc, more would gradually follow for the same reason followed by the Dutch, Swedish and Germans. This was encouraged given that it was viewed as a means of getting the settlements to grow and become established. However, from the 1640s, African involuntary immigration began, where slaves from mostly West†¦show more content†¦While the States only mostly complained at first with no real changes, these policies brought about real changes, and were impactful. These laws were aimed at ensuring that other nations did not send criminals to the various States, who would only make progress for these S tates more difficult. On the other hand, this was also meant to show Britain that the United States was independent and would not longer bend to any influence. 3. From 1875, a number of laws had started being enacted creating restrictions on immigration. While a number of laws had been passed earlier (1862 and 69) to regulate Chinese labor (this was meant to deal with cheap Chinese labor), the Act of 1875 was implemented and outlawed the importation of women for prostitution purposes as well as prohibiting other alien convicts. In 1882, another immigration law was passed by Congress, imposing a federal tax (50 cents) on every passenger that arrived from foreign countries. This was also aimed at controlling the numbers of those who entered the United States. 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